What should I avoid while taking bupropion? Drinking alcohol with Wellbutrin XL may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. Pictures of Wellbutrin (Bupropion Hcl), drug imprint information, side effects for the patient. Bupropion can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine. How should I take Wellbutrin? Beating cancer takes more than medicine. That’s why we do much more than breakthrough research. We also o er free rides to chemo, a live 24/7 helpline, and free lodging near hospitals for people dealing with every type of cancer. We’re attacking from every angle. Mixing alcohol and drugs is never a good idea. Whether they are over-the-counter prescription meds or illegal drugs, taking them with booze can have fatal consequences. Alcohol and Wellbutrin shouldn’t be combined. If you do drink alcohol and take Wellbutrin, it’s recommended that you drink only on a very limited basis. How to Cure a Stomach Ache. Stomach aches can become a distracting discomfort that keep you from some of your favorite activities. The internet is full of information about this, and fortunately, we've dug through it to find that first. “Can I drink alcohol with this medication?” This is a question doctors are asked a lot. 55% of Americans regularly take prescription medications and 30% of Americans have at least one alcoholic drink every day. “Can I drink alcohol with this medication?” This is a question doctors are asked a lot. 55% of Americans regularly take prescription medications and 30% of Americans have at least one alcoholic drink every day. Doctors' Answers to Frequently Asked Questions - Wellbutrin. These comments are made for the purpose of discussion and should NOT be used as recommendations for or against therapies or other treatments.